Pharmacokinetics of high-dose oral thiamine hydrochloride in healthy subjects.
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ABSTRACT:
SUBMITTER: Smithline HA
PROVIDER: S-EPMC3293077 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Publications
Pharmacokinetics of high-dose oral thiamine hydrochloride in healthy subjects.
Smithline Howard A HA Donnino Michael M Greenblatt David J DJ
BMC clinical pharmacology 20120204
<h4>Background</h4>High dose oral thiamine may have a role in treating diabetes, heart failure, and hypermetabolic states. The purpose of this study was to determine the pharmacokinetic profile of oral thiamine hydrochloride at 100 mg, 500 mg and 1500 mg doses in healthy subjects.<h4>Methods</h4>This was a randomized, double-blind, single-dose, 4-way crossover study. Pharmacokinetic measures were calculated.<h4>Results</h4>The AUC₀₋₁₀ hr and C(max) values increased nonlinearly between 100 mg and ...[more]
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