Ontology highlight
ABSTRACT:
SUBMITTER: Kohen R
PROVIDER: S-EPMC3293495 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Journal of geriatric psychiatry and neurology 20110408 2
The ABCB1 gene, coding for the efflux transporter P-glycoprotein (PGP), is a candidate gene for Alzheimer disease (AD). P-glycoprotein is heavily expressed at the blood-brain barrier, where it mediates the efflux of β-amyloid (Aβ) from the brain. In this study, we investigated a possible association between 2 common ABCB1 polymorphisms, G2677T/A (Ala893Ser/Thr) and C3435T, AD, and cerebrospinal fluid (CSF) levels of Aβ. No strong evidence for association was found. ...[more]