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ABCB1 genotype and CSF beta-amyloid in Alzheimer disease.

ABSTRACT: The ABCB1 gene, coding for the efflux transporter P-glycoprotein (PGP), is a candidate gene for Alzheimer disease (AD). P-glycoprotein is heavily expressed at the blood-brain barrier, where it mediates the efflux of ?-amyloid (A?) from the brain. In this study, we investigated a possible association between 2 common ABCB1 polymorphisms, G2677T/A (Ala893Ser/Thr) and C3435T, AD, and cerebrospinal fluid (CSF) levels of A?. No strong evidence for association was found.

SUBMITTER: Kohen R

PROVIDER: S-EPMC3293495 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature

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ABCB1 genotype and CSF beta-amyloid in Alzheimer disease.

Kohen R R Shofer J B JB Korvatska O O Petrie E C EC Wang L Y LY Schellenberg G D GD Peskind E R ER Wilkinson C W CW

Journal of geriatric psychiatry and neurology 20110408 2

The ABCB1 gene, coding for the efflux transporter P-glycoprotein (PGP), is a candidate gene for Alzheimer disease (AD). P-glycoprotein is heavily expressed at the blood-brain barrier, where it mediates the efflux of β-amyloid (Aβ) from the brain. In this study, we investigated a possible association between 2 common ABCB1 polymorphisms, G2677T/A (Ala893Ser/Thr) and C3435T, AD, and cerebrospinal fluid (CSF) levels of Aβ. No strong evidence for association was found. ...[more]

PMID: 21478475

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