Ontology highlight
ABSTRACT:
SUBMITTER: Rettig GR
PROVIDER: S-EPMC3293614 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Rettig Garrett R GR Behlke Mark A MA
Molecular therapy : the journal of the American Society of Gene Therapy 20111220 3
RNA interference (RNAi) has been extensively employed for in vivo research since its use was first demonstrated in mammalian cells 10 years ago. Design rules have improved, and it is now routinely possible to obtain reagents that suppress expression of any gene desired. At the same time, increased understanding of the molecular basis of unwanted side effects has led to the development of chemical modification strategies that mitigate these concerns. Delivery remains the single greatest hurdle to ...[more]