Ontology highlight
ABSTRACT:
SUBMITTER: Lanitis E
PROVIDER: S-EPMC3293635 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Lanitis Evripidis E Poussin Mathilde M Hagemann Ian S IS Coukos George G Sandaltzopoulos Raphael R Scholler Nathalie N Powell Daniel J DJ
Molecular therapy : the journal of the American Society of Gene Therapy 20111129 3
Cancer regression by gene-modified T cells bearing a chimeric antigen receptor (CAR) exodomain of mouse origin can be limited by the induction of transgene immunogenicity resulting in poor persistence and function in vivo. The development of functionally-active CAR of human origin can address this issue. Here, we constructed and evaluated fully human anti-mesothelin CARs comprised of a human mesothelin-specific single-chain antibody variable fragment (P4 scFv) coupled to T cell signaling domains ...[more]