Ontology highlight
ABSTRACT:
SUBMITTER: Navarro M
PROVIDER: S-EPMC3294264 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Journal of inorganic biochemistry 20110922 12
Three platinum-chloroquine complexes, trans-Pt(CQDP)(2)(I)(2) [1], trans-Pt(CQDP)(2)(Cl)(2) [2] and trans-Pt(CQ)(2)(Cl)(2) [3], were prepared and their most probable structure was established through a combination of spectroscopic analysis and density functional theory (DFT) calculations. Their interaction with DNA was studied and their activity against 6 tumor cell lines was evaluated. Compounds 1 and 2 interact with DNA primarily through electrostatic contacts and hydrogen bonding, with a mino ...[more]