Ontology highlight
ABSTRACT:
SUBMITTER: Wong MY
PROVIDER: S-EPMC3294265 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Wong Man Yan MY Zhou Chaoming C Shakiryanova Dinara D Lloyd Thomas E TE Deitcher David L DL Levitan Edwin S ES
Cell 20120301 5
Neurotransmission requires anterograde axonal transport of dense core vesicles (DCVs) containing neuropeptides and active zone components from the soma to nerve terminals. However, it is puzzling how one-way traffic could uniformly supply sequential release sites called en passant boutons. Here, Drosophila neuropeptide-containing DCVs are tracked in vivo for minutes with a new method called simultaneous photobleaching and imaging (SPAIM). Surprisingly, anterograde DCVs typically bypass proximal ...[more]