Ontology highlight
ABSTRACT:
SUBMITTER: Li D
PROVIDER: S-EPMC3294303 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Li Dong D Scott Lena L Crambert Susanne S Zelenin Sergey S Eklöf Ann-Christine AC Di Ciano Luis L Ibarra Fernando F Aperia Anita A
Journal of the American Society of Nephrology : JASN 20111222 3
Signaling through both angiotensin AT1 receptors (AT1R) and dopamine D1 receptors (D1R) modulates renal sodium excretion and arterial BP. AT1R and D1R form heterodimers, but whether treatment with AT1R antagonists functionally modifies D1R via allosterism is unknown. In this study, the AT1R antagonist losartan strengthened the interaction between AT1R and D1R and increased expression of D1R on the plasma membrane in vitro. In rat proximal tubule cells that express endogenous AT1R and D1R, losart ...[more]