Ontology highlight
ABSTRACT:
SUBMITTER: Cho Y
PROVIDER: S-EPMC3294498 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Cho Yoonsang Y Vermeire Jon J JJ Merkel Jane S JS Leng Lin L Du Xin X Bucala Richard R Cappello Michael M Lolis Elias E
Chemistry & biology 20110901 9
The screening of bioactive compound libraries can be an effective approach for repositioning FDA-approved drugs or discovering new pharmacophores. Hookworms are blood-feeding, intestinal nematode parasites that infect up to 600 million people worldwide. Vaccination with recombinant Ancylostoma ceylanicum macrophage migration inhibitory factor (rAceMIF) provided partial protection from disease, thus establishing a "proof-of-concept" for targeting AceMIF to prevent or treat infection. A high-throu ...[more]