Ontology highlight
ABSTRACT:
SUBMITTER: Troke PJ
PROVIDER: S-EPMC3294886 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Troke Philip J F PJ Lewis Marilyn M Simpson Paul P Gore Katrina K Hammond Jennifer J Craig Charles C Westby Mike M
Antimicrobial agents and chemotherapy 20111227 3
Filibuvir (PF-00868554) is an investigational nonnucleoside inhibitor of the hepatitis C virus (HCV) nonstructural 5B (NS5B) RNA-dependent RNA polymerase currently in development for treating chronic HCV infection. The aim of this study was to characterize the selection of filibuvir-resistant variants in HCV-infected individuals receiving filibuvir as short (3- to 10-day) monotherapy. We identified amino acid M423 as the primary site of mutation arising upon filibuvir dosing. Through bulk clonin ...[more]