Ontology highlight
ABSTRACT:
SUBMITTER: Sader HS
PROVIDER: S-EPMC3294907 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Antimicrobial agents and chemotherapy 20120109 3
BC-3781 is a novel semisynthetic pleuromutilin antimicrobial agent developed as an intravenous and oral therapy for acute bacterial skin and skin structure infections (ABSSSI) and respiratory tract infections (RTI). BC-3781 and comparator agents were tested by the broth microdilution method against 1,893 clinical Gram-positive organisms predominantly causing ABSSSI. BC-3781 exhibited potent activity against methicillin-resistant Staphylococcus aureus (MIC(50/90), 0.12/0.25 μg/ml), coagulase-nega ...[more]