Ontology highlight
ABSTRACT:
SUBMITTER: Pena AC
PROVIDER: S-EPMC3294911 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Pena Ana C AC Penacho Nuno N Mancio-Silva Liliana L Neres Rita R Seixas João D JD Fernandes Afonso C AC Romão Carlos C CC Mota Maria M MM Bernardes Gonçalo J L GJ Pamplona Ana A
Antimicrobial agents and chemotherapy 20111212 3
Severe forms of malaria infection, such as cerebral malaria (CM) and acute lung injury (ALI), are mainly caused by the apicomplexan parasite Plasmodium falciparum. Primary therapy with quinine or artemisinin derivatives is generally effective in controlling P. falciparum parasitemia, but mortality from CM and other forms of severe malaria remains unacceptably high. Herein, we report the design and synthesis of a novel carbon monoxide-releasing molecule (CO-RM; ALF492) that fully protects mice ag ...[more]