Ontology highlight
ABSTRACT:
SUBMITTER: Lee SC
PROVIDER: S-EPMC3295290 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Lee Sang-Chul SC Park Keunwan K Han Jieun J Lee Joong-jae JJ Kim Hyun Jung HJ Hong Seungpyo S Heu Woosung W Kim Yu Jung YJ Ha Jae-Seok JS Lee Seung-Goo SG Cheong Hae-Kap HK Jeon Young Ho YH Kim Dongsup D Kim Hak-Sung HS
Proceedings of the National Academy of Sciences of the United States of America 20120210 9
Repeat proteins have recently been of great interest as potential alternatives to immunoglobulin antibodies due to their unique structural and biophysical features. We here present the development of a binding scaffold based on variable lymphocyte receptors, which are nonimmunoglobulin antibodies composed of Leucine-rich repeat modules in jawless vertebrates, by module engineering. A template scaffold was first constructed by joining consensus repeat modules between the N- and C-capping motifs o ...[more]