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1,2-Bis[(3,6,9-trimethyl-3,12-ep-oxy-3,4,5,5a,6,7,8,8a,9,10,12,12a-dodeca-hydro-pyrano[4,3-j][1,2]benzodioxepin-4-yl)-oxy]ethane.

ABSTRACT: The title compound, C(32)H(50)O(10), prepared from a mixture of ?- and ?-dihydro-artemisinin, has two ?-arteether moieties linked via an -OCH(2)CH(2)O- bridge, so that the mol-ecule is symmetric about the bridge. Each asymmetric unit contains a ?-arteether moiety and an -OCH(2) group, which is only one-half of the mol-ecule. The endo-peroxide bridges of the parent compounds have been retained in each half of the diol-bridged dimer. The rings exhibit chair and twist-boat conformations.

SUBMITTER: Jia L 

PROVIDER: S-EPMC3295452 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature

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1,2-Bis[(3,6,9-trimethyl-3,12-ep-oxy-3,4,5,5a,6,7,8,8a,9,10,12,12a-dodeca-hydro-pyrano[4,3-j][1,2]benzodioxepin-4-yl)-oxy]ethane.

Jia Liwei L   Yue Zhengyu Z   Lv Dongying D   Gao Po P  

Acta crystallographica. Section E, Structure reports online 20120210 Pt 3

The title compound, C(32)H(50)O(10), prepared from a mixture of α- and β-dihydro-artemisinin, has two β-arteether moieties linked via an -OCH(2)CH(2)O- bridge, so that the mol-ecule is symmetric about the bridge. Each asymmetric unit contains a β-arteether moiety and an -OCH(2) group, which is only one-half of the mol-ecule. The endo-peroxide bridges of the parent compounds have been retained in each half of the diol-bridged dimer. The rings exhibit chair and twist-boat conformations. ...[more]

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