4-[(4-Amino-phen-yl)sulfon-yl]aniline-3,5-dinitro-benzoic acid (1/1).

ABSTRACT: The title compound, C(7)H(4)N(2)O(6)·C(12)H(12)N(2)O(2)S, is a 1:1 cocrystal of the drug dapsone with 3,5-dinitro-benzoic acid. The dihedral angle between the two aromatic rings of the dapsone mol-ecule is 75.4?(2)°, and the dihedral angles between these rings and that of the 3,5-dinitro-benzoic acid are 64.5?(2) and 68.4?(2)°. A strong inter-molecular carb-oxy-lic acid O-H?N(amine) hydrogen bond is found, together with inter-molecular amine N-H?O hydrogen-bonding associations with carboxyl, nitro and sulfone O-atom acceptors. In addition, weak ?-? inter-actions between one of the dapsone benzene rings and the 3,5-dinitro-benzoic acid ring [ring centroid separation = 3.774?(2)?Å] results in a two-dimensional network structure.

SUBMITTER: Smith G 

PROVIDER: S-EPMC3295457 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature