Detailed mitochondrial phenotyping by high resolution metabolomics.
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ABSTRACT:
SUBMITTER: Roede JR
PROVIDER: S-EPMC3295783 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Publications
Detailed mitochondrial phenotyping by high resolution metabolomics.
Roede James R JR Park Youngja Y Li Shuzhao S Strobel Frederick H FH Jones Dean P DP
PloS one 20120306 3
Mitochondrial phenotype is complex and difficult to define at the level of individual cell types. Newer metabolic profiling methods provide information on dozens of metabolic pathways from a relatively small sample. This pilot study used "top-down" metabolic profiling to determine the spectrum of metabolites present in liver mitochondria. High resolution mass spectral analyses and multivariate statistical tests provided global metabolic information about mitochondria and showed that liver mitoch ...[more]
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