Ontology highlight
ABSTRACT:
SUBMITTER: Kovacevic I
PROVIDER: S-EPMC3295921 | biostudies-literature | 2012 Jan-Feb
REPOSITORIES: biostudies-literature
Kovacevic Ismar I Ho Richard R Cram Erin J EJ
Mechanisms of development 20120120 11-12
The Caenorhabditis elegans distal tip cells (DTCs) are an in vivo model for the study of developmentally regulated cell migration. In this study, we characterize a novel role for CCDC-55, a conserved coiled-coil domain containing protein, in DTC migration and larval development in C. elegans. Although animals homozygous for a probable null allele, ccdc-55(ok2851), display an early larval arrest, RNAi depletion experiments allow the analysis of later phenotypes and suggest that CCDC-55 is needed ...[more]