The potential for BRAF V600 inhibitors in advanced cutaneous melanoma: rationale and latest evidence.
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ABSTRACT:
SUBMITTER: Lemech C
PROVIDER: S-EPMC3296083 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Publications
The potential for BRAF V600 inhibitors in advanced cutaneous melanoma: rationale and latest evidence.
Lemech Charlotte C Infante Jeffrey J Arkenau Hendrik-Tobias HT
Therapeutic advances in medical oncology 20120301 2
Historically, patients with advanced cutaneous melanoma have a poor prognosis and limited treatment options. The discovery of selective v-raf murine sarcoma viral oncogene homolog B1 (BRAF) V600 mutation as an oncogenic mutation in cutaneous melanoma and the importance of the mitogen-activated protein kinase (MAPK) pathway in its tumourigenesis have changed the treatment paradigm for melanoma. Selective BRAF inhibitors and now MEK inhibitors have demonstrated response rates far higher than stand ...[more]
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