Ontology highlight
ABSTRACT:
SUBMITTER: Maynard ND
PROVIDER: S-EPMC3296357 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Maynard Nathaniel D ND Macklin Derek N DN Kirkegaard Karla K Covert Markus W MW
Molecular systems biology 20120131
Viral infection depends on a complex interplay between host and viral factors. Here, we link host susceptibility to viral infection to a network encompassing sulfur metabolism, tRNA modification, competitive binding, and programmed ribosomal frameshifting (PRF). We first demonstrate that the iron-sulfur cluster biosynthesis pathway in Escherichia coli exerts a protective effect during lambda phage infection, while a tRNA thiolation pathway enhances viral infection. We show that tRNA(Lys) uridine ...[more]