Ontology highlight
ABSTRACT:
SUBMITTER: Savas JN
PROVIDER: S-EPMC3296478 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Savas Jeffrey N JN Toyama Brandon H BH Xu Tao T Yates John R JR Hetzer Martin W MW
Science (New York, N.Y.) 20120202 6071
To combat the functional decline of the proteome, cells use the process of protein turnover to replace potentially impaired polypeptides with new functional copies. We found that extremely long-lived proteins (ELLPs) did not turn over in postmitotic cells of the rat central nervous system. These ELLPs were associated with chromatin and the nuclear pore complex, the central transport channels that mediate all molecular trafficking in and out of the nucleus. The longevity of these proteins would b ...[more]