Ontology highlight
ABSTRACT:
SUBMITTER: Nguyen KD
PROVIDER: S-EPMC3296631 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Nguyen Khoa D KD Macaubas Claudia C Nadeau Kari C KC Truong Phi P Yoon Taejin T Lee Tzielan T Park Jane L JL Mellins Elizabeth D ED
Blood 20110216 14
The acute phase protein serum amyloid A (SAA) has been well characterized as an indicator of inflammation. Nevertheless, its functions in pro versus anti-inflammatory processes remain obscure. Here we provide unexpected evidences that SAA induces the proliferation of the tolerogenic subset of regulatory T cells (T(reg)). Intriguingly, SAA reverses T(reg) anergy via its interaction with monocytes to activate distinct mitogenic pathways in T(reg) but not effector T cells. This selective responsive ...[more]