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A sterol and spiroditerpenoids from a Penicillium sp. isolated from a deep sea sediment sample.

ABSTRACT: A new polyoxygenated sterol, sterolic acid (1), three new breviane spiroditerpenoids, breviones I-K (2-4), and the known breviones (5-8), were isolated from the crude extract of a Penicillium sp. obtained from a deep sea sediment sample that was collected at a depth of 5115 m. The structures of 1-4 were elucidated primarily by NMR experiments, and 1 was further confirmed by X-ray crystallography. The absolute configurations of 2 and 3 were deduced by comparison of their CD spectra with those of the model compounds. Compounds 2 and 5 showed significant cytotoxicity against MCF-7 cells, which is comparable to the positive control cisplatin.

SUBMITTER: Li Y

PROVIDER: S-EPMC3297011 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature

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A sterol and spiroditerpenoids from a Penicillium sp. isolated from a deep sea sediment sample.

Li Yan Y Ye Dezan D Shao Zongze Z Cui Chengbin C Che Yongsheng Y

Marine drugs 20120220 2

A new polyoxygenated sterol, sterolic acid (1), three new breviane spiroditerpenoids, breviones I-K (2-4), and the known breviones (5-8), were isolated from the crude extract of a Penicillium sp. obtained from a deep sea sediment sample that was collected at a depth of 5115 m. The structures of 1-4 were elucidated primarily by NMR experiments, and 1 was further confirmed by X-ray crystallography. The absolute configurations of 2 and 3 were deduced by comparison of their CD spectra with those of ...[more]

PMID: 22412815

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