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Chaperone-usher pathways: diversity and pilus assembly mechanism.

ABSTRACT: Up to eight different types of secretion systems, and several more subtypes, have been described in Gram-negative bacteria. Here, we focus on the diversity and assembly mechanism of one of the best-studied secretion systems, the widespread chaperone-usher pathway known to assemble and secrete adhesive surface structures, called pili or fimbriae, which play essential roles in targeting bacterial pathogens to the host.

SUBMITTER: Busch A

PROVIDER: S-EPMC3297437 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature

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Chaperone-usher pathways: diversity and pilus assembly mechanism.

Busch Andreas A Waksman Gabriel G

Philosophical transactions of the Royal Society of London. Series B, Biological sciences 20120401 1592

Up to eight different types of secretion systems, and several more subtypes, have been described in Gram-negative bacteria. Here, we focus on the diversity and assembly mechanism of one of the best-studied secretion systems, the widespread chaperone-usher pathway known to assemble and secrete adhesive surface structures, called pili or fimbriae, which play essential roles in targeting bacterial pathogens to the host. ...[more]

PMID: 22411982

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Structural Insight into Archaic and Alternative Chaperone-Usher Pathways Reveals a Novel Mechanism of Pilus Biogenesis.

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The Cryoelectron Microscopy Structure of the Type 1 Chaperone-Usher Pilus Rod.

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