Ontology highlight
ABSTRACT:
SUBMITTER: LaCasse CJ
PROVIDER: S-EPMC3297475 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
LaCasse Collin J CJ Janikashvili Nona N Larmonier Claire B CB Alizadeh Darya D Hanke Neale N Kartchner Jessica J Situ Elaine E Centuori Sara S Har-Noy Michael M Bonnotte Bernard B Katsanis Emmanuel E Larmonier Nicolas N
Journal of immunology (Baltimore, Md. : 1950) 20111109 12
Dendritic cells (DCs) encompass a heterogeneous population of cells capable of orchestrating innate and adaptive immune responses. The ability of DCs to act as professional APCs has been the foundation for the development and use of these cells as vaccines in cancer immunotherapy. DCs are also endowed with the nonconventional property of directly killing tumor cells. The current study investigates the regulation of murine DC cytotoxic function by T lymphocytes. We provide evidence that CD4(+) Th ...[more]