Quantitative Proteomics of Intracellular Campylobacter jejuni Reveals Metabolic Reprogramming.
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ABSTRACT:
SUBMITTER: Liu X
PROVIDER: S-EPMC3297583 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Publications
Quantitative Proteomics of Intracellular Campylobacter jejuni Reveals Metabolic Reprogramming.
Liu Xiaoyun X Gao Beile B Novik Veronica V Galán Jorge E JE
PLoS pathogens 20120308 3
Campylobacter jejuni is the major cause of bacterial food-borne illness in the USA and Europe. An important virulence attribute of this bacterial pathogen is its ability to enter and survive within host cells. Here we show through a quantitative proteomic analysis that upon entry into host cells, C. jejuni undergoes a significant metabolic downshift. Furthermore, our results indicate that intracellular C. jejuni reprograms its respiration, favoring the respiration of fumarate. These results expl ...[more]
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