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Tuberculin skin test reactivity is dependent on host genetic background in Colombian tuberculosis household contacts.

ABSTRACT: The tuberculin skin test (TST) measures the intensity of antimycobacterial acquired immunity and is used to diagnose latent infection with Mycobacterium tuberculosis. We report evidence for a codominant gene explaining ?65% of the TST variability. Disregarding the host genetic background may lead to misclassifications of TST-based diagnosis of latent M. tuberculosis infection.

SUBMITTER: Cobat A 

PROVIDER: S-EPMC3297651 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature

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Tuberculin skin test reactivity is dependent on host genetic background in Colombian tuberculosis household contacts.

Cobat Aurélie A   Barrera Luis F LF   Henao Hanna H   Arbeláez Patricia P   Abel Laurent L   García Luis F LF   Schurr Erwin E   Alcaïs Alexandre A  

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20120130 7

The tuberculin skin test (TST) measures the intensity of antimycobacterial acquired immunity and is used to diagnose latent infection with Mycobacterium tuberculosis. We report evidence for a codominant gene explaining ∼65% of the TST variability. Disregarding the host genetic background may lead to misclassifications of TST-based diagnosis of latent M. tuberculosis infection. ...[more]

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