Regulation of aldo-keto reductases in human diseases.
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ABSTRACT:
SUBMITTER: Chen WD
PROVIDER: S-EPMC3297832 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Publications
Regulation of aldo-keto reductases in human diseases.
Chen Wei-Dong WD Zhang Yanqiao Y
Frontiers in pharmacology 20120309
The aldo-keto reductases (AKRs) are a superfamily of NAD(P)H-linked oxidoreductases, which reduce aldehydes and ketones to their respective primary and secondary alcohols. AKR enzymes are increasingly being recognized to play an important role in the transformation and detoxification of aldehydes and ketones generated during drug detoxification and xenobiotic metabolism. Many transcription factors have been identified to regulate the expression of human AKR genes, which could have profound effec ...[more]
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