Ontology highlight
ABSTRACT:
SUBMITTER: Antonucci F
PROVIDER: S-EPMC3297996 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Antonucci Flavia F Turola Elena E Riganti Loredana L Caleo Matteo M Gabrielli Martina M Perrotta Cristiana C Novellino Luisa L Clementi Emilio E Giussani Paola P Viani Paola P Matteoli Michela M Verderio Claudia C
The EMBO journal 20120113 5
Microvesicles (MVs) released into the brain microenvironment are emerging as a novel way of cell-to-cell communication. We have recently shown that microglia, the immune cells of the brain, shed MVs upon activation but their possible role in microglia-to-neuron communication has never been explored. To investigate whether MVs affect neurotransmission, we analysed spontaneous release of glutamate in neurons exposed to MVs and found a dose-dependent increase in miniature excitatory postsynaptic cu ...[more]