Ontology highlight
ABSTRACT:
SUBMITTER: Cho MH
PROVIDER: S-EPMC3298111 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Cho Michael H MH Castaldi Peter J PJ Wan Emily S ES Siedlinski Mateusz M Hersh Craig P CP Demeo Dawn L DL Himes Blanca E BE Sylvia Jody S JS Klanderman Barbara J BJ Ziniti John P JP Lange Christoph C Litonjua Augusto A AA Sparrow David D Regan Elizabeth A EA Make Barry J BJ Hokanson John E JE Murray Tanda T Hetmanski Jacqueline B JB Pillai Sreekumar G SG Kong Xiangyang X Anderson Wayne H WH Tal-Singer Ruth R Lomas David A DA Coxson Harvey O HO Edwards Lisa D LD MacNee William W Vestbo Jørgen J Yates Julie C JC Agusti Alvar A Calverley Peter M A PM Celli Bartolome B Crim Courtney C Rennard Stephen S Wouters Emiel E Bakke Per P Gulsvik Amund A Crapo James D JD Beaty Terri H TH Silverman Edwin K EK
Human molecular genetics 20111111 4
The genetic risk factors for chronic obstructive pulmonary disease (COPD) are still largely unknown. To date, genome-wide association studies (GWASs) of limited size have identified several novel risk loci for COPD at CHRNA3/CHRNA5/IREB2, HHIP and FAM13A; additional loci may be identified through larger studies. We performed a GWAS using a total of 3499 cases and 1922 control subjects from four cohorts: the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE); t ...[more]