Ontology highlight
ABSTRACT:
SUBMITTER: Narisawa A
PROVIDER: S-EPMC3298276 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Narisawa Ayumi A Komatsuzaki Shoko S Kikuchi Atsuo A Niihori Tetsuya T Aoki Yoko Y Fujiwara Kazuko K Tanemura Mitsuyo M Hata Akira A Suzuki Yoichi Y Relton Caroline L CL Grinham James J Leung Kit-Yi KY Partridge Darren D Robinson Alexis A Stone Victoria V Gustavsson Peter P Stanier Philip P Copp Andrew J AJ Greene Nicholas D E ND Tominaga Teiji T Matsubara Yoichi Y Kure Shigeo S
Human molecular genetics 20111213 7
Neural tube defects (NTDs), including spina bifida and anencephaly, are common birth defects of the central nervous system. The complex multigenic causation of human NTDs, together with the large number of possible candidate genes, has hampered efforts to delineate their molecular basis. Function of folate one-carbon metabolism (FOCM) has been implicated as a key determinant of susceptibility to NTDs. The glycine cleavage system (GCS) is a multi-enzyme component of mitochondrial folate metabolis ...[more]