Ontology highlight
ABSTRACT:
SUBMITTER: Parker ZM
PROVIDER: S-EPMC3298365 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Parker Zachary M ZM Pendergraft Samuel S SS Sobieraj Jim J McGinnis Marcus M MM Karatan Ece E
FEMS microbiology letters 20120130 1
Biofilm formation in Vibrio cholerae is in part regulated by norspermidine, a polyamine synthesized by the enzyme carboxynorspermidine decarboxylase (NspC). The absence of norspermidine in the cell leads to a marked reduction in V. cholerae biofilm formation by an unknown mechanism. In this work, we show that overexpression of nspC results in large increases in biofilm formation and vps gene expression as well as a significant decrease in motility. Interestingly, increased NspC levels do not lea ...[more]