Ontology highlight
ABSTRACT:
SUBMITTER: Abel S
PROVIDER: S-EPMC3298681 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Abel Sören S Chien Peter P Wassmann Paul P Schirmer Tilman T Kaever Volkhard V Laub Michael T MT Baker Tania A TA Jenal Urs U
Molecular cell 20110801 4
In Caulobacter crescentus, phosphorylation of key regulators is coordinated with the second messenger cyclic di-GMP to drive cell-cycle progression and differentiation. The diguanylate cyclase PleD directs pole morphogenesis, while the c-di-GMP effector PopA initiates degradation of the replication inhibitor CtrA by the AAA+ protease ClpXP to license S phase entry. Here, we establish a direct link between PleD and PopA reliant on the phosphodiesterase PdeA and the diguanylate cyclase DgcB. PdeA ...[more]