Ontology highlight
ABSTRACT:
SUBMITTER: Morgan EA
PROVIDER: S-EPMC3299366 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Morgan Elizabeth A EA Nascimento Alessandra F AF
Advances in hematology 20120226
Anaplastic lymphoma kinase-(ALK-) positive large B-cell lymphoma (ALK+ LBCL) is a rare, aggressive tumor characterized by an immunoblastic or plasmablastic morphologic appearance, expression of ALK, CD138, CD45, EMA, and often IgA by immunohistochemistry, and characteristic chromosomal translocations or rearrangements involving the ALK locus. The morphologic and immunophenotypic overlap of this tumor with other hematologic and nonhematologic malignancies may result in misdiagnosis. The tumor has ...[more]