Ontology highlight
ABSTRACT:
SUBMITTER: Hanson AJ
PROVIDER: S-EPMC3299836 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Hanson Alison J AJ Wallace Heather A HA Freeman Tanner J TJ Beauchamp R Daniel RD Lee Laura A LA Lee Ethan E
Molecular cell 20120201 5
A key event in Wnt signaling is conversion of TCF/Lef from a transcriptional repressor to an activator, yet how this switch occurs is not well understood. Here, we report an unanticipated role for X-linked inhibitor of apoptosis (XIAP) in regulating this critical Wnt signaling event that is independent of its antiapoptotic function. We identified DIAP1 as a positive regulator of Wingless signaling in a Drosophila S2 cell-based RNAi screen. XIAP, its vertebrate homolog, is similarly required for ...[more]