Mutational robustness of an RNA virus influences sensitivity to lethal mutagenesis.
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ABSTRACT:
SUBMITTER: Graci JD
PROVIDER: S-EPMC3302263 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Publications
Mutational robustness of an RNA virus influences sensitivity to lethal mutagenesis.
Graci Jason D JD Gnädig Nina F NF Galarraga Jessica E JE Castro Christian C Vignuzzi Marco M Cameron Craig E CE
Journal of virology 20111221 5
The ability to extinguish a viral population of fixed reproductive capacity by causing small changes in the mutation rate is referred to as lethal mutagenesis and is a corollary of population genetics theory. Here we show that coxsackievirus B3 (CVB3) exhibits reduced mutational robustness relative to poliovirus, manifesting in enhanced sensitivity of CVB3 to lethal mutagens that is dependent on the size of the viral population. We suggest that mutational robustness may be a useful measure of th ...[more]
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