Ontology highlight
ABSTRACT:
SUBMITTER: Egawa N
PROVIDER: S-EPMC3302310 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Egawa Nagayasu N Nakahara Tomomi T Ohno Shin-Ichi S Narisawa-Saito Mako M Yugawa Takashi T Fujita Masatoshi M Yamato Kenji K Natori Yukikazu Y Kiyono Tohru T
Journal of virology 20120111 6
Papillomavirus genomes are thought to be amplified to about 100 copies per cell soon after infection, maintained constant at this level in basal cells, and amplified for viral production upon keratinocyte differentiation. To determine the requirement for E1 in viral DNA replication at different stages, an E1-defective mutant of the human papillomavirus 16 (HPV16) genome featuring a translation termination mutation in the E1 gene was used. The ability of the mutant HPV16 genome to replicate as nu ...[more]