Choline intake in a large cohort of patients with nonalcoholic fatty liver disease.

ABSTRACT:

Background

There is significant histologic and biochemical overlap between nonalcoholic fatty liver disease (NAFLD) and steatohepatitis associated with choline deficiency.

Objective

We sought to determine whether subjects with biopsy-proven NAFLD and evidence of an inadequate intake of choline had more severe histologic features.

Design

We performed a cross-sectional analysis of 664 subjects enrolled in the multicenter, prospective Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN) with baseline data on diet composition (from a recall-based food-frequency questionnaire) within 6 mo of a liver biopsy. Food questionnaires were analyzed with proprietary software to estimate daily intakes of choline. Liver biopsies were centrally read, and consensus was sco

SUBMITTER: Guerrerio AL 

PROVIDER: S-EPMC3302364 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature