Ontology highlight
ABSTRACT:
SUBMITTER: Lauck M
PROVIDER: S-EPMC3302523 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Lauck Michael M Alvarado-Mora Mónica V MV Becker Ericka A EA Bhattacharya Dipankar D Striker Rob R Hughes Austin L AL Carrilho Flair J FJ O'Connor David H DH Pinho João R Rebello JR
Journal of virology 20120125 7
Hepatitis C virus (HCV) is the leading cause of liver disease worldwide. In this study, we analyzed four treatment-naïve patients infected with subtype 1a and performed Roche/454 pyrosequencing across the coding region. We report the presence of low-level drug resistance mutations that would most likely have been missed using conventional sequencing methods. The approach described here is broadly applicable to studies of viral diversity and could help to improve the efficacy of direct-acting ant ...[more]