Ontology highlight
ABSTRACT:
SUBMITTER: Stevens LJ
PROVIDER: S-EPMC3302734 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Stevens Laura J LJ Page-McCaw Andrea A
Molecular biology of the cell 20120119 6
Matrix metalloproteinases (MMPs) are extracellular proteases highly expressed at wound sites. However, the precise function of MMPs during reepithelialization in vivo has been elusive in mammalian models because of the high level of redundancy among the 24 mammalian MMPs. For this reason we used Drosophila melanogaster, whose genome encodes only two MMPs-one secreted type (Mmp1) and one membrane-anchored type (Mmp2)-to study the function and regulation of the secreted class of MMPs in vivo. In t ...[more]