Ontology highlight
ABSTRACT:
SUBMITTER: Harrell JC
PROVIDER: S-EPMC3303043 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Harrell J Chuck JC Prat Aleix A Parker Joel S JS Fan Cheng C He Xiaping X Carey Lisa L Anders Carey C Ewend Matthew M Perou Charles M CM
Breast cancer research and treatment 20110614 2
The ability to predict metastatic potential could be of great clinical importance, however, it is uncertain if predicting metastasis to specific vital organs is feasible. As a first step in evaluating metastatic predictions, we analyzed multiple primary tumors and metastasis pairs and determined that >90% of 298 gene expression signatures were found to be similarly expressed between matched pairs of tumors and metastases; therefore, primary tumors may be a good predictor of metastatic propensity ...[more]