Ontology highlight
ABSTRACT:
SUBMITTER: Faith JJ
PROVIDER: S-EPMC3303606 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Faith Jeremiah J JJ McNulty Nathan P NP Rey Federico E FE Gordon Jeffrey I JI
Science (New York, N.Y.) 20110519 6038
The interrelationships between our diets and the structure and operations of our gut microbial communities are poorly understood. A model community of 10 sequenced human gut bacteria was introduced into gnotobiotic mice, and changes in species abundance and microbial gene expression were measured in response to randomized perturbations of four defined ingredients in the host diet. From the responses, we developed a statistical model that predicted over 60% of the variation in species abundance e ...[more]