Ontology highlight
ABSTRACT:
SUBMITTER: Martinez-Archundia M
PROVIDER: S-EPMC3303834 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Martinez-Archundia Marlet M Cordomi Arnau A Garriga Pere P Perez Juan J JJ
Journal of biomedicine & biotechnology 20120227
The present study reports the results of a combined computational and site mutagenesis study designed to provide new insights into the orthosteric binding site of the human M3 muscarinic acetylcholine receptor. For this purpose a three-dimensional structure of the receptor at atomic resolution was built by homology modeling, using the crystallographic structure of bovine rhodopsin as a template. Then, the antagonist N-methylscopolamine was docked in the model and subsequently embedded in a lipid ...[more]