Ontology highlight
ABSTRACT:
SUBMITTER: Rajule R
PROVIDER: S-EPMC3303926 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Bioorganic & medicinal chemistry 20120216 7
In HeLa cells the combinatorial knockdown of Bcl-xL and Mcl-1 is sufficient to induce spontaneous apoptosis. Quinoxaline derivatives were screened for the induction of Mcl-1 dependent apoptosis using a cell line without functional Bcl-xL. Quinoxaline urea analog 1 h was able to specifically induce apoptosis in an Mcl-1 dependent manner. We demonstrate that even small changes to 1h results in dramatic loss of activity. In addition, 1 h and ABT-737 synergistically inhibit cell growth and induce ap ...[more]