Ontology highlight
ABSTRACT:
SUBMITTER: Guthridge JM
PROVIDER: S-EPMC3304673 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Guthridge Joel M JM Clark Daniel N DN Templeton Amanda A Dominguez Nicolas N Lu Rufei R Vidal Gabriel S GS Kelly Jennifer A JA Kauffman Kenneth M KM Harley John B JB Gaffney Patrick M PM James Judith A JA Poole Brian D BD
Journal of biomedicine & biotechnology 20120222
Both genetic and environmental interactions affect systemic lupus erythematosus (SLE) development and pathogenesis. One known genetic factor associated with lupus is a haplotype of the interferon regulatory factor 5 (IRF5) gene. Analysis of global gene expression microarray data using gene set enrichment analysis identified multiple interferon- and inflammation-related gene sets significantly overrepresented in cells with the risk haplotype. Pathway analysis using expressed genes from the signif ...[more]