Ontology highlight
ABSTRACT:
SUBMITTER: Raoul W
PROVIDER: S-EPMC3305292 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Raoul William W Poupel Lucie L Tregouet David-Alexandre DA Lavalette Sophie S Camelo Serge S Keller Nicole N Krumeich Sophie S Calippe Bertrand B Guillonneau Xavier X Behar-Cohen Francine F Cohen Salomon-Yves SY Baatz Holger H Combadière Christophe C Théry Clotilde C Sennlaub Florian F
PloS one 20120315 3
<h4>Purpose</h4>Milk fat globule-epidermal growth factor-factor VIII (MFGE8) is necessary for diurnal outer segment phagocytosis and promotes VEGF-dependent neovascularization. The prevalence of two single nucleotide polymorphisms (SNP) in MFGE8 was studied in two exsudative or "wet" Age-related Macular Degeneration (AMD) groups and two corresponding control groups. We studied the effect of MFGE8 deficiency on retinal homeostasis with age and on choroidal neovascularization (CNV) in mice.<h4>Met ...[more]