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Animal models of dyssynchrony.


ABSTRACT: Cardiac resynchronization therapy (CRT) is an important therapy for patients with heart failure and conduction pathology, but the benefits are heterogeneous between patients and approximately a third of patients do not show signs of clinical or echocardiographic response. This calls for a better understanding of the underlying conduction disease and resynchronization. In this review, we discuss to what extent established and novel animal models can help to better understand the pathophysiology of dyssynchrony and the benefits of CRT.

SUBMITTER: Strik M 

PROVIDER: S-EPMC3306020 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature

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Animal models of dyssynchrony.

Strik Marc M   van Middendorp Lars B LB   Vernooy Kevin K  

Journal of cardiovascular translational research 20111201 2


Cardiac resynchronization therapy (CRT) is an important therapy for patients with heart failure and conduction pathology, but the benefits are heterogeneous between patients and approximately a third of patients do not show signs of clinical or echocardiographic response. This calls for a better understanding of the underlying conduction disease and resynchronization. In this review, we discuss to what extent established and novel animal models can help to better understand the pathophysiology o  ...[more]

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