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Implication of European-derived adiposity loci in African Americans.


ABSTRACT: Recent genome-wide association studies (GWAS) have identified multiple novel loci associated with adiposity in European-derived study populations. Limited study of these loci has been reported in African Americans. Here we examined the effects of these previously identified adiposity loci in African Americans.A total of 46 representative single-nucleotide polymorphisms (SNPs) in 19 loci that were previously reported in GWAS in Europeans (including FTO and MC4R) were genotyped in 4992 subjects from six African-American cohorts. These SNPs were tested for association with body mass index (BMI) after adjustment for age, gender, disease status and population structure in each cohort. Meta-analysis was conducted to combine the results.Meta-analysis of 4992 subjects revealed seven SNPs near four loci, including NEGR1, TMEM18, SH2B1 /ATP2A1 and MC4R, showing significant association at 0.005

SUBMITTER: Hester JM 

PROVIDER: S-EPMC3306054 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature

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Implication of European-derived adiposity loci in African Americans.

Hester J M JM   Wing M R MR   Li J J   Palmer N D ND   Xu J J   Hicks P J PJ   Roh B H BH   Norris J M JM   Wagenknecht L E LE   Langefeld C D CD   Freedman B I BI   Bowden D W DW   Ng M C Y MC  

International journal of obesity (2005) 20110712 3


<h4>Objective</h4>Recent genome-wide association studies (GWAS) have identified multiple novel loci associated with adiposity in European-derived study populations. Limited study of these loci has been reported in African Americans. Here we examined the effects of these previously identified adiposity loci in African Americans.<h4>Methods</h4>A total of 46 representative single-nucleotide polymorphisms (SNPs) in 19 loci that were previously reported in GWAS in Europeans (including FTO and MC4R)  ...[more]

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