Ontology highlight
ABSTRACT:
SUBMITTER: Solit DB
PROVIDER: S-EPMC3306236 | biostudies-literature | 2006 Jan
REPOSITORIES: biostudies-literature
Solit David B DB Garraway Levi A LA Pratilas Christine A CA Sawai Ayana A Getz Gad G Basso Andrea A Ye Qing Q Lobo Jose M JM She Yuhong Y Osman Iman I Golub Todd R TR Sebolt-Leopold Judith J Sellers William R WR Rosen Neal N
Nature 20051106 7074
The kinase pathway comprising RAS, RAF, mitogen-activated protein kinase kinase (MEK) and extracellular signal regulated kinase (ERK) is activated in most human tumours, often through gain-of-function mutations of RAS and RAF family members. Using small-molecule inhibitors of MEK and an integrated genetic and pharmacologic analysis, we find that mutation of BRAF is associated with enhanced and selective sensitivity to MEK inhibition when compared to either 'wild-type' cells or cells harbouring a ...[more]