Ontology highlight
ABSTRACT:
SUBMITTER: Zhou D
PROVIDER: S-EPMC3306455 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Zhou Dongwen D Chung Suhman S Miller Maria M Grice Stuart F J Le SF Wlodawer Alexander A
Journal of structural biology 20120216 3
The ribonuclease H (RNase H) domain of retroviral reverse transcriptase (RT) plays a critical role in the life cycle by degrading the RNA strands of DNA/RNA hybrids. In addition, RNase H activity is required to precisely remove the RNA primers from nascent (-) and (+) strand DNA. We report here three crystal structures of the RNase H domain of xenotropic murine leukemia virus-related virus (XMRV) RT, namely (i) the previously identified construct from which helix C was deleted, (ii) the intact d ...[more]