Prediction and characterization of protein-protein interaction networks in swine.

ABSTRACT:

Background

Studying the large-scale protein-protein interaction (PPI) network is important in understanding biological processes. The current research presents the first PPI map of swine, which aims to give new insights into understanding their biological processes.

Results

We used three methods, Interolog-based prediction of porcine PPI network, domain-motif interactions from structural topology-based prediction of porcine PPI network and motif-motif interactions from structural topology-based prediction of porcine PPI network, to predict porcine protein interactions among 25,767 porcine proteins. We predicted 20,213, 331,484, and 218,705 porcine PPIs respectively, merged the three results into 567,441 PPIs, constructed four PPI networks, and analyzed the topological proper

SUBMITTER: Wang F 

PROVIDER: S-EPMC3306829 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature