Exact coalescent simulation of new haplotype data from existing reference haplotypes.
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ABSTRACT:
SUBMITTER: Kang CJ
PROVIDER: S-EPMC3307111 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Publications
Exact coalescent simulation of new haplotype data from existing reference haplotypes.
Kang Chul Joo CJ Marjoram Paul P
Bioinformatics (Oxford, England) 20120117 6
<h4>Motivation</h4>We introduce a coalescent-based method (RECOAL) for the simulation of new haplotype data from a reference population of haplotypes. A coalescent genealogy for the reference haplotype data is sampled from the appropriate posterior probability distribution, then a coalescent genealogy is simulated which extends the sampled genealogy to include new haplotype data. The new haplotype data will, therefore, contain both some of the existing polymorphic sites and new polymorphisms add ...[more]
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